Transposable elements (TEs), which constitute nearly half of the human genome, were once deemed ‘junk DNA’. However, recent technological advancements have led to a resurgence of research interest into their functional impact and molecular mechanism, particularly focusing on the major Type I TEs (also known as Endogenous Retrotransposable Elements or EREs). These elements, integrated into the human genome over millions of years, have undergone evolutionary changes that now make them influential factors in human biology. EREs represent a rich yet understudied source of regulatory sequences that drive the evolution of human genomes and epigenomic landscape. ERE dysregulation has been widely reported in human diseases including cancer, neurodegenerative diseases, and aging. The primary goal of this meeting will be to facilitate the exchange of ideas among academic scientists and clinical researchers from diverse backgrounds. This Fusion meeting will boost unconventional interactions and foster innovative, cross-disciplinary ideas and collaborations that could transform existing paradigms.